Recent publication
Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex
March 1, 2022
Nguyen LH, Leiser SC, Song D, Brunner D, Roberds SL, Wong M, Bordey A. Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex. Epilepsy Res. 2022 Mar;181:106890. doi: 10.1016/j.eplepsyres.2022.106890. Epub 2022 Feb 18. PMID: 35219048; PMCID: PMC8930622.
Brain stimulation treatments in epilepsy: Basic mechanisms and clinical advances
February 1, 2022
Foutz TJ, Wong M. Brain stimulation treatments in epilepsy: Basic mechanisms and clinical advances. Biomed J. 2022 Feb;45(1):27-37. doi: 10.1016/j.bj.2021.08.010. Epub 2021 Sep 2. PMID: 34482013; PMCID: PMC9133258.
Illuminating Seizures: Combined Optical and Electrophysiological Recording Techniques Provide Novel Insights Into Seizure Dynamics
October 20, 2021
Foutz TJ, Wong M. Illuminating Seizures: Combined Optical and Electrophysiological Recording Techniques Provide Novel Insights Into Seizure Dynamics. Epilepsy Curr. 2021 Oct 20;22(1):78-80. doi: 10.1177/15357597211053682. PMID: 35233209; PMCID: PMC8832359.
Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress
September 1, 2021
Zimmer TS, Korotkov A, Zwakenberg S, Jansen FE, Zwartkruis FJT, Rensing NR, Wong M, Mühlebner A, van Vliet EA, Aronica E, Mills JD. Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress. Brain Pathol. 2021 Sep;31(5):e12949. doi: 10.1111/bpa.12949. Epub 2021 Mar 30. PMID: 33786950; PMCID: PMC8412124.
Add-on Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex: A Placebo-Controlled Randomized Clinical Trial
March 1, 2021
Thiele EA, Bebin EM, Bhathal H, Jansen FE, Kotulska K, Lawson JA, O’Callaghan FJ, Wong M, Sahebkar F, Checketts D, Knappertz V; GWPCARE6 Study Group. Add-on Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex: A Placebo-Controlled Randomized Clinical Trial. JAMA Neurol. 2021 Mar 1;78(3):285-292. doi: 10.1001/jamaneurol.2020.4607. PMID: 33346789; PMCID: PMC7754080.
Recent publications
- Drug-Resistant Epilepsy in Tuberous Sclerosis Complex Is Associated With TSC2 Genotype: More Findings From the Preventing Epilepsy Using Vigatrin (PREVeNT) TrialPREVENT Study Group, Oct 2024, In: Pediatric Neurology. 159, p. 62-71 10 p.Research output: Contribution to journal › Article › peer-review
- A role of dentate gyrus mechanistic target of rapamycin activation in epileptogenesis in a mouse model of posttraumatic epilepsyGuo, D., Han, L., Godale, C. M., Rensing, N. R., Danzer, S. C. & Wong, M., Jul 2024, In: Epilepsia. 65, 7, p. 2127-2137 11 p.Research output: Contribution to journal › Article › peer-review
- Periodic and aperiodic changes to cortical EEG in response to pharmacological manipulationSalvatore, S. V., Lambert, P. M., Benz, A., Rensing, N. R., Wong, M., Zorumski, C. F. & Mennerick, S., Mar 2024, In: Journal of neurophysiology. 131, 3, p. 529-540 12 p.Research output: Contribution to journal › Article › peer-review
- Cerebral vascular and blood brain–barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complexGuo, D., Zhang, B., Han, L., Rensing, N. R. & Wong, M., Feb 2024, In: Epilepsia. 65, 2, p. 483-496 14 p.Research output: Contribution to journal › Article › peer-review
- Spatial and amplitude dynamics of neurostimulation: Insights from the acute intrahippocampal kainate seizure mouse modelFoutz, T. J., Rensing, N., Han, L., Durand, D. M. & Wong, M., Feb 2024, In: Epilepsia Open. 9, 1, p. 210-222 13 p.Research output: Contribution to journal › Article › peer-review
- Early Treatment with Vigabatrin Does Not Decrease Focal Seizures or Improve Cognition in Tuberous Sclerosis Complex: The PREVeNT TrialBebin, E. M., Peters, J. M., Porter, B. E., McPherson, T. O., O'Kelley, S., Sahin, M., Taub, K. S., Rajaraman, R., Randle, S. C., McClintock, W. M., Koenig, M. K., Frost, M. D., Northrup, H. A., Werner, K., Nolan, D. A., Wong, M., Krefting, J. L., Biasini, F., Peri, K. & Cutter, G. & 1 others, Krueger, D. A., Jan 2024, In: Annals of neurology. 95, 1, p. 15-26 12 p.Research output: Contribution to journal › Article › peer-review
- Laser interstitial thermal therapy compared with open resection for treating subependymal giant cell astrocytomaAum, D. J., Reynolds, R. A., McEvoy, S. D., Wong, M., Roland, J. L. & Smyth, M. D., Jan 2024, In: Journal of Neurosurgery: Pediatrics. 33, 1, p. 95-104 10 p.Research output: Contribution to journal › Article › peer-review
- Subependymal giant-cell astrocytomas in the absence of tuberous sclerosisReynolds, R. A., Aum, D. J., Gonzalez-Gomez, I., Wong, M., Roberts, K., Dahiya, S., Rodriguez, L. F., Roland, J. L. & Smyth, M. D., Sep 2023, In: Journal of Neurosurgery: Pediatrics. 32, 3, p. 351-357 7 p.Research output: Contribution to journal › Article › peer-review
- Gene therapy ameliorates spontaneous seizures associated with cortical neuron loss in a Cln2R207X mouse modelTakahashi, K., Eultgen, E. M., Wang, S. H., Rensing, N. R., Nelvagal, H. R., Dearborn, J. T., Danos, O., Buss, N., Sands, M. S., Wong, M. & Cooper, J. D., Jun 15 2023, In: Journal of Clinical Investigation. 133, 12, e165908.Research output: Contribution to journal › Article › peer-review
- Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in miceTsuji, S., Brace, C. S., Yao, R., Tanie, Y., Tada, H., Rensing, N., Mizuno, S., Almunia, J., Kong, Y., Nakamura, K., Furukawa, T., Ogiso, N., Toyokuni, S., Takahashi, S., Wong, M., Imai, S. I. & Satoh, A., Jun 1 2023, In: Life Science Alliance. 6, 6Research output: Contribution to journal › Article › peer-review